SHORT REPORT

Biochemical changes as a result of prolonged strenuous exercise

D E R Warburton, R C Welsh, M J Haykowsky, D A Taylor, D P Humen

Division of Cardiology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada

Correspondence to:
Correspondence to:
Dr Warburton, Allan McGavin Sports Medicine Centre, 3055 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;
darrenwb{at}interchange.ubc.ca

Objective: To briefly review biochemical changes that may result from prolonged strenuous exercise and to relate these changes to health risk.

Methods: Medline and Sports Discus databases were searched for relevant articles. Additional articles were found using cross referencing and the authors' knowledge of the subject area.

Results: Prolonged strenuous exercise may result in a series of biochemical changes that are of concern from a health point of view. Generally, these changes are benign, but some, especially hyponatraemia, are potentially life threatening occurrences.

Conclusion: Doctors and athletes should be aware of the potentially adverse biochemical changes, especially hyponatraemia, that may result from prolonged strenuous exercise.

Keywords: exercise; hyponatraemia; biochemical changes

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