SHORT REPORT

Does complete deficiency of muscle actinin 3 alter functional capacity in elderly women? A preliminary report

A F San Juan, F Gomez-Gallego, S Cañete, C Santiago, M Pérez and A Lucia

Universidad Europea de Madrid, Spain

Correspondence to:
Correspondence to:
Professor Lucia
Universidad Europea de Madrid, Madrid 28670, Spain; alejandro.lucia{at}uem.es

The sarcomeric protein actinin 3 is localised to the Z line of fast fibres, which are responsible for generating forceful muscle contractions at high velocity. However, a substantial proportion of healthy humans are totally deficient in this protein as they are homozygous for a premature stop codon polymorphism (R577X) in the ACTN3 gene. The purpose of this preliminary study was to assess if the presence or absence of actinin 3 influences the deleterious effects of ageing on muscle output and functional capacity.

Keywords: ACTN3 gene; ageing; muscle; functional capacity; strength

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Online short reports
Br. J. Sports Med. 2006 40: 54. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Delmonico, M. J., Zmuda, J. M., Taylor, B. C., Cauley, J. A., Harris, T. B., Manini, T. M., Schwartz, A., Li, R., Roth, S. M., Hurley, B. F., Bauer, D. C., Ferrell, R. E., Newman, A. B., for the Health ABC and MrOS Research Groups, (2008). Association of the ACTN3 Genotype and Physical Functioning With Age in Older Adults. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 63: 1227-1234 [Abstract] [Full Text]  
• Walsh, S., Liu, D., Metter, E. J., Ferrucci, L., Roth, S. M. (2008). ACTN3 genotype is associated with muscle phenotypes in women across the adult age span. J. Appl. Physiol. 105: 1486-1491 [Abstract] [Full Text]  
• Delmonico, M. J., Kostek, M. C., Doldo, N. A., Hand, B. D., Walsh, S., Conway, J. M., Carignan, C. R., Roth, S. M., Hurley, B. F. (2007). Alpha-Actinin-3 (ACTN3) R577X Polymorphism Influences Knee Extensor Peak Power Response to Strength Training in Older Men and Women. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62: 206-212 [Abstract] [Full Text]