SHORT REPORT

Does complete deficiency of muscle actinin 3 alter functional capacity in elderly women? A preliminary report

A F San Juan, F Gomez-Gallego, S Cañete, C Santiago, M Pérez, A Lucia

Universidad Europea de Madrid, Spain

Correspondence to:
Correspondence to:
Professor Lucia
Universidad Europea de Madrid, Madrid 28670, Spain; alejandro.lucia{at}uem.es

The sarcomeric protein actinin 3 is localised to the Z line of fast fibres, which are responsible for generating forceful muscle contractions at high velocity. However, a substantial proportion of healthy humans are totally deficient in this protein as they are homozygous for a premature stop codon polymorphism (R577X) in the ACTN3 gene. The purpose of this preliminary study was to assess if the presence or absence of actinin 3 influences the deleterious effects of ageing on muscle output and functional capacity.

Keywords: ACTN3 gene; ageing; muscle; functional capacity; strength

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Br. J. Sports Med. 2006 40: 54. [Extract] [Full Text] [PDF]

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