ORIGINAL ARTICLE

Resistance exercise does not affect the serum concentrations of cell adhesion molecules

Anatoli Petridou¹, Athanasios Chatzinikolaou², Ioannis Fatouros², George Mastorakos³, Asimina Mitrakou⁴, Helen Chandrinou⁵, Ioannis Papassotiriou⁶, Vassilis Mougios¹

¹ Department of Physical Education and Sport Science, Aristotle University of Thessaloniki, Thessaloniki, Greece
² Department of Physical Education and Sport Science, Democritus University of Thrace, Thrace, Greece
³ Endocrine Unit, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece
⁴ Department of Internal Medicine, Henry Dunant Hospital, Athens, Greece
⁵ Blood Transfusion Service, Henry Dunant Hospital, Athens, Greece
⁶ Department of Clinical Biochemistry, "Aghia Sophia" Children’s Hospital, Athens, Greece

Correspondence to:
Dr Vassilis Mougios
TEFAA, University of Thessaloniki, 541 24 Thessaloniki, Greece; mougios{at}phed.auth.gr

Background: Cell adhesion molecules are proteins expressed on the surface of a variety of cells and mediate the leucocyte response to inflammation. Some of these molecules are released to the plasma as soluble forms, whose presence indicates the degree of vascular endothelial activation or dysfunction. Increased concentrations of soluble adhesion molecules are thought to hamper the immune response and mediate the atherosclerotic inflammatory process. Studies on the effect of exercise on the concentrations of soluble adhesion molecules have almost exclusively used aerobic exercise.

Aim: To assess the effect of resistance exercise on the serum concentrations of five cell adhesion molecules during and immediately after 30 min of exercise in lean and obese participants.

Methods: Fourteen healthy young men (eight lean and six obese) performed 3 sets of 10 resistance exercises with 10–12 repetitions at 70–75% of one repetition maximum in a circuit training fashion. Venous blood samples were drawn at baseline and at the end of the first, second and third sets. The serum concentrations of vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, E-selectin, P-selectin and L-selectin were measured in a biochip array analyser.

Results: No significant changes were observed in the concentrations of these cell adhesion molecules during exercise, or between lean and obese participants.

Conclusion: Our data indicate that resistance exercise of moderate to high intensity does not affect the serum concentrations of cell adhesion molecules in healthy young lean or obese men, suggesting no considerable negative effect on immune function.

Abbreviations: BMI, body mass index; ICAM, intercellular cell adhesion molecule; VCAM, vascular cell adhesion molecule

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Commentary

Katarzyna Mizia-Stec⁷

⁷ Silesian University School of Medicine, Katowice, Poland; kmizia{at}op.pl

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