ORIGINAL ARTICLES

Effects of acute prednisolone administration on exercise endurance and metabolism

A Arlettaz¹, K Collomp^1,2, H Portier¹, A-M Lecoq^1,3, N Rieth¹, B Le Panse¹, J De Ceaurriz²

¹ LAPSEP, Faculty of Sport Science, University of Orléans, Orléans, France
² Département des Analyses, AFLD,Chatenay-Malabry, France
³ Sports Medicine Service, CHR Orléans, France

K Collomp, LAPSEP, UFR STAPS, 2, Allée du Château, BP6237 45062 Orléans Cedex 2, France; katia.collomp{at}univ-orleans.fr

Objective: To examine whether acute glucocorticoid (GC) intake alters performance and selected hormonal and metabolic variables during submaximal exercise.

Methods: In total, 14 recreational male athletes completed two cycling trials at 70–75% maximum O₂ uptake starting 3 h after an ingestion of either a lactose placebo or oral GC (20 mg of prednisolone) and continuing until exhaustion, according to a double-blind randomised protocol. Blood samples were collected at rest, after 10, 20, 30 minutes, and at exhaustion and recovery for measurement of growth hormone (GH), adrenocorticotropic hormone (ACTH), dehydroepiandrosterone (DHEA), prolactin, insulin, blood glucose, lactate and interleukin (IL)-6 determination.

Results: Cycling duration was not significantly changed after GC or placebo administration (55.9 (5.2) v 48.8 (2.9) minutes, respectively). A decrease in ACTH and DHEA (p<0.01) was observed with GC during all of the experiments and in IL-6 after exhaustion (p<0.05). No change in basal, exercise or recovery GH, prolactin, insulin or lactate was found between the two treatments but blood glucose was significantly higher with GC (p<0.05) at any time point.

Conclusion: From these data, acute systemic GC administration does seem to alter some metabolic markers but did not influence performance during submaximal exercise.

Keywords: glucocorticoid; oral intake; performance; submaximal exercise; hormone

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Commentary 1 on "Effects of acute prednisolone administration on exercise endurance and metabolism"

Michel Audran
Br. J. Sports Med. 2008 42: 254. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Collomp, K, Arlettaz, A, Portier, H, Lecoq, A-M, Le Panse, B, Rieth, N, De Ceaurriz, J (2008). Short-term glucocorticoid intake combined with intense training on performance and hormonal responses. Br. J. Sports. Med. 42: 983-988 [Abstract] [Full Text]