LEADER

Tendinopathies

Understanding tendinopathies

G A Murrell

Orthopaedic Research Institute, St George Hospital, University of New South Wales, Sydney, Australia

Correspondence to:
Correspondence to:
Professor Murrell, Research and Education Center, 4–10 South St, Kogarah, Sydney, NSW 2217, Australia;
admin@ori.org.au

---

Is apoptosis the heart of the problem?

---

Keywords: tendon; tendinopathy; apoptosis

The first 150 words of the full text of this article appear below.

One of the "banes" of most health professionals who look after athletes and workers is tendinopathies. What causes them? What gets them better? Recently there have been several advances that may contribute to our understanding of these disorders.

We all know that tendinopathies occur in the tendinous portion of musculotendinous units that cross joints, often two joints—for example, the extensor carpi radialis brevis in tennis elbow, the patellar tendon in jumpers knee—and that they occur in situations of repetitive, high, often eccentric loading. The classic pathology is a loss of the normal collagenous architecture and replacement with an amorphous mucinous material that lacks the parallel, longitudinal architecture of normal tendon.¹ Soslowsky et al² made a major advance when they developed an animal model that could reproduce many of the microscopic changes of supraspinatus tendinopathy. The model involved running rats on a treadmill for up to an hour a day . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Lippi, G., Longo, U. G., Maffulli, N. (2009). Genetics and sports. Br Med Bull 0: ldp007v1-21 [Abstract] [Full Text]  
• September, A. V, Schwellnus, M. P, Collins, M., Gibson, W. (2007). Tendon and ligament injuries: the genetic component * COMMENTARY. Br. J. Sports. Med. 41: 241-246 [Full Text]  
• Neville, V J, Molloy, J, Brooks, J H M, Speedy, D B, Atkinson, G, Spalding, T, Allen, J B (2006). Epidemiology of injuries and illnesses in America's Cup yacht racing * Commentary * Commentary.. Br. J. Sports. Med. 40: 304-312 [Abstract] [Full Text]  
• Mokone, G. G., Gajjar, M., September, A. V., Schwellnus, M. P., Greenberg, J., Noakes, T. D., Collins, M. (2005). The Guanine-Thymine Dinucleotide Repeat Polymorphism Within the Tenascin-C Gene Is Associated With Achilles Tendon Injuries. Am J Sports Med 33: 1016-1021 [Abstract] [Full Text]  
• Scott, A, Khan, K M, Heer, J, Cook, J L, Lian, O, Duronio, V (2005). High strain mechanical loading rapidly induces tendon apoptosis: an ex vivo rat tibialis anterior model. Br. J. Sports. Med. 39: e25-e25 [Abstract] [Full Text]  
• Scott, A, Duronio, V (2003). Understanding tendinopathies. Br. J. Sports. Med. 37: 279-279 [Full Text]