LEADER

Inflammatory response

The inflammatory response: friend or enemy for muscle injury?

H Toumi, T M Best

Departments of Orthopedics and Rehabilitation and Family Medicine, University of Wisconsin, Madison, WI, USA

Correspondence to:
Correspondence to:
Dr Toumi, 501 North Henry Street (appart 812), Madison, WI 53703, USA;
htoumi@wisc.edu

---

Limiting certain aspects of inflammation may be a useful new treatment for sport related muscle injury

---

Keywords: inflammatory response; muscle; injury; neutrophils; ischaemia

The first 150 words of the full text of this article appear below.

Muscle injury can occur through diverse mechanisms such as mechanical injury, muscular dystrophies, infectious diseases, and biochemical toxicities. Several types of skeletal muscle injury fall into the broad category of sport and exercise induced muscle injury. When exercise involves eccentric muscular contractions, it is associated with overloading of the contractile elements and connective tissues—that is, the force requirement of the muscle exceeds the habitual requirements—and can result in injury to skeletal muscle. It has traditionally been felt that the events following the initial injury, including inflammation, are necessary for optimal repair. The inflammatory response to eccentric exercise as well as stretch injury consist of neutrophilia, neutrophil activation, and the accumulation of neutrophils within the injured muscle as early as one to two hours. In this early inflammatory stage, cellular debris is removed by the infiltrating neutrophils and is followed by a regenerative response during which satellite cells proliferate . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Paoloni, J A, Milne, C, Orchard, J, Hamilton, B (2009). Non-steroidal anti-inflammatory drugs in sports medicine: guidelines for practical but sensible use. Br. J. Sports. Med. 43: 863-865 [Abstract] [Full Text]  
• Paulsen, G., Vissing, K., Kalhovde, J. M., Ugelstad, I., Bayer, M. L., Kadi, F., Schjerling, P., Hallen, J., Raastad, T. (2007). Maximal eccentric exercise induces a rapid accumulation of small heat shock proteins on myofibrils and a delayed HSP70 response in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293: R844-R853 [Abstract] [Full Text]  
• Shireman, P. K., Contreras-Shannon, V., Ochoa, O., Karia, B. P., Michalek, J. E., McManus, L. M. (2007). MCP-1 deficiency causes altered inflammation with impaired skeletal muscle regeneration. J. Leukoc. Biol. 81: 775-785 [Abstract] [Full Text]  
• Jarvinen, T. A. H., Jarvinen, T. L. N., Kaariainen, M., Kalimo, H., Jarvinen, M. (2005). Muscle Injuries: Biology and Treatment. Am J Sports Med 33: 745-764 [Abstract] [Full Text]  
• Scott, A, Khan, K M, Roberts, C R, Cook, J L, Duronio, V (2004). What do we mean by the term "inflammation"? A contemporary basic science update for sports medicine. Br. J. Sports. Med. 38: 372-380 [Abstract] [Full Text]