LEADER

TENDINOPATHY

Reactive oxygen species and tendinopathy: do they matter?

C S Bestwick¹, N Maffulli²

¹ Phytochemical and Genomic Stability Group, Cellular Integrity Programme, Rowett Research Institute, Aberdeen, Scotland, UK
² Keele University School of Medicine, Trauma and Orthopaedics, Hartshill, UK

Correspondence to:
Correspondence to:
Professor Maffulli
Keele University School of Medicine, Trauma and Orthopaedics, Thornburrow Drive, Hartshill ST4 7QB, UK; osa14@keele.ac.uk

---

Reactive oxygen species are probably involved in tendinopathy

---

Abbreviations: PDGF, platelet derived growth factor; RNS, reactive nitrogen species; ROS, reactive oxygen species

Keywords: tendinopathy; tendinoses; reactive oxygen species; antioxidants; exercise

The first 150 words of the full text of this article appear below.

We propose that a molecular link between the exaggerated dysfunctional repair response in overuse tendinopathies and the subsequent orchestration of effective tendon healing is the control of the production and persistence of reactive oxygen species within the intracellular and extracellular milieu of the tendon tissue. Reactive oxygen production and the ensuing cellular response can be strongly influenced by lifestyle factors such as the intensity and frequency of exercise.

"Reactive oxygen species" (ROS; also referred to as active oxygen species, AOS; reactive oxygen intermediates, ROI) is a collective term for both radical and non-radical but reactive species derived from oxygen. A free radical, is "any species capable of independent existence that contains one or more unpaired electrons".¹ The presence of such unpaired electron(s) often imparts considerable reactivity. Commonly detected and potentially physiologically relevant ROS include the superoxide anion, hydrogen peroxide (H₂O₂), the hydroxyl radical, singlet oxygen, and peroxyl . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Kane, T. P. C., Ismail, M., Calder, J. D. F. (2008). Topical Glyceryl Trinitrate and Noninsertional Achilles Tendinopathy: A Clinical and Cellular Investigation. Am J Sports Med 36: 1160-1163 [Abstract] [Full Text]