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Baker KR, Xu L, Zhang Y, et al. Arthritis & Rheumatism 2004;50:1815–21[CrossRef][Medline]
Background: Muscle weakness has been associated with tibiofemoral knee osteoarthritis (OA) and may cause OA due to reduced shock absorption during impulse loading at heel strike, when the patellofemoral joint is not engaged.
Research question/s: Is muscle weakness associated with compartment-specific knee OA, are there gender differences, and are symptoms associated with weakness?
Methodology: subjects: 2472 subjects (female = 1475, male = 997) (>60 yrs).
Experimental procedure: All subjects underwent radiography to defined subjects with (1) tibiofemoral (TF) OA when the Kellgren/Lawrence (K/L) grade >2 on AP/PA view; (2) patellofemoral (PF) OA (skyline view with osteophyte score >2 or when the JSN score was >2 and the osteophyte score was >1); and (3) mixed (MX) OA when the knee had both patellofemoral and tibiofemoral radiographic OA. Muscle strength was measured isometrically for
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