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Skeletal muscle damage

Can oestrogen influence skeletal muscle damage, inflammation, and repair?

P M Tiidus

Correspondence to:
Correspondence to:
Professor Tiidus
Wilfrid Laurier University, Kinesiology and Physical Education, Waterloo, Ontario N2L 3C5, Canada; ptiidus@wlu.ca

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More research is needed before the use of oestrogen can be recommended for muscle damage

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Keywords: oestrogen; muscle damage; muscle repair; inflammation

The first 150 words of the full text of this article appear below.

Oestrogen may affect muscle damage and inflammation, but the physiological significance of this, particularly potential effects on muscle repair and recovery in humans, and the mechanisms of its actions are as of yet unknown.

Over the last decade, evidence has accumulated that oestrogen may act to diminish skeletal muscle damage and inflammatory responses after unaccustomed exercise or other damaging insult. These prophylactic effects are similar to the effect of oestrogen in diminishing damage and inflammation in other tissues such as cardiac muscle, liver, and nervous tissue.^1–3 What is not clear is the physiological significance of this effect of oestrogen and whether it is physiologically meaningful or results in significantly differential responses in skeletal muscle after over-exertion in humans.⁴ The mechanisms by which oestrogen exerts its effect on skeletal muscle responses to damaging exercise, and whether its influence extends to differential rates of muscle repair and recovery also . . . [Full text of this article]

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This article has been cited by other articles:

• Hubal, M. J., Clarkson, P. M. (2009). Counterpoint: Estrogen and Sex do not Significantly Influence Post-Exercise Indexes of Muscle Damage, Inflammation, and Repair. J. Appl. Physiol. 106: 1012-1014 [Full Text]  
• (2009). Rebuttal from Drs. Tiidus and Enns. J. Appl. Physiol. 106: 1014-1014 [Full Text]