British Journal of Sports Medicine 2006;40:895-896
EDITORIAL
COX-2 inhibitors
COX-2 inhibitors in sports medicine: utility and controversy
1 Rush-Presbyterian-St Luke’s Medical Center, Chicago, IL, USA
2 Tufts University School of Medicine, Boston, MA, USA
Correspondence to:
Dr Buvanendran
Rush-Presbyterian-St Luke’s Medical Center, Chicago, IL 60612, USA; asokumar@aol.com
Short term use of COX-2 inhibitors for pain management is recommended
Keywords: COX-2 inhibitors
| The first 150 words of the full text of this article appear below. |
There are approximately 4.2 million visits annually to emergency rooms for non-fatal sports and recreation related injuries in the US.1 Sports injury leads to the release of phospholipids from cell membranes, which are converted into arachidonic acid by the action of phospholipase A2. Arachidonic acid in turn acts as a substrate for cyclo-oxygenase (COX) resulting in the production of various prostaglandins (PGs). There are two forms of COX: COX-1 (constitutively present) and COX-2 (induced). Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit both types of COX enzymes, whereas COX-2-specific inhibitors inhibit only the COX-2 enzyme. COX-2 inhibitors were developed with the aim of reducing the incidence of serious adverse gastrointestinal effects associated with the administration of traditional NSAIDs. The assumption was that gastrointestinal side effects were COX-1-mediated. There are two major reasons for the use of NSAIDs and COX-2 inhibitors in the treatment of athletic injuries: to decrease excessive inflammation
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