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Serum enzymes

Monitoring of serum enzymes in sport

P Brancaccio¹, F M Limongelli¹, N Maffulli²

¹ Department of Experimental Medicine, Centre of Excellence of Cardiovascular Disease, Seconda Università degli Studi di Napoli, Napoli, Italy
² Department of Trauma and Orthopaedic Surgery, Keele University School of Medicine, Stoke on Trent, Staffordshire, UK

Correspondence to:
Correspondence to:
Professor Maffulli
Department of Trauma and Orthopaedic Surgery, Keele University School of Medicine, Thornburrow Drive, Hartshill, Stoke on Trent ST4 7QB, Staffordshire, UK; osa14@keele.ac.uk

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Monitoring of creatine kinase and lactate dehydrogenase can reveal the state of the muscle and its biochemical adaptation to physical load

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Keywords: exercise; muscle pathology; serum enzymes; training

The first 150 words of the full text of this article appear below.

Functional assessment of athletes’ fitness includes a variety of variables. Serum creatine kinase (CK) and lactate dehydrogenase (LDH) give an indication of the degree of metabolic adaptation to physical training of skeletal muscles. Both enzymes are involved in muscle metabolism, and their serum concentration is normally very low, a result of physiological wear and tear of the cell. They increase considerably after intensive exercise and in muscle pathology.^1,2

Changes in serum activity of muscle enzymes have been reported in normal subjects and athletes after strenuous exercise.^3–6 The amount of enzyme efflux from muscle tissue to serum can be influenced by physical exercise.⁷ Also, there are ethnic differences,⁸ and the differences between the sexes have been attributed to the protective effects of oestrogen on muscle cell membrane.⁹

Muscle biopsy findings have evidenced different activity of total LDH and LDH isozymes in endurance and strength athletes. The former had lower . . . [Full text of this article]

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This article has been cited by other articles:

• Brancaccio, P., Maffulli, N., Limongelli, F. M. (2007). Creatine kinase monitoring in sport medicine. Br Med Bull 0: ldm014v1-22 [Abstract] [Full Text]  

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