British Journal of Sports Medicine 2007;41:346-348
LEADER
GROWTH HORMONE AND EXERCISE
Exercise modulation of growth hormone isoforms: current knowledge and future directions for the exercise endocrinologist
Correspondence to:
Dr B C Nindl
Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, MA 1760, USA; bradley.nindl@na.amedd.army.mil
Accepted 6 January 2007
Importance of growth hormone molecular heterogeneity as a partial mechanism for somatogenic adaptations to physical activity
| The first 150 words of the full text of this article appear below. |
Growth hormone (GH) exhibits a great deal of molecular heterogeneity (there are over 100 isoforms in circulation) and we are only beginning to understand how exercise influences concentrations of GH isoforms.
As the field of exercise endocrinology moves forward in the 21st century, greater recognition will be given to molecular heterogeneity that exists for many protein hormones within the paradigm of exercise and physical activity. Specifically, it is well established, but not well recognised, that GH exhibits a great deal of molecular heterogeneity, as over 100 molecular isoforms are thought to exist in the circulation. The importance of gaining a greater understanding of the exercise-mediated influences on GH molecular heterogeneity resides in the fact that the GH isoforms have diverse downstream metabolic and anabolic actions in target tissues.
The human GH-N gene expresses the main pituitary molecular mass variant in the GH family, which is the
Exercise and Sport Science Laboratories, University of Memphis, Memphis, Tennessee, USA; afry@memphis.edu
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