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Published Online First: 23 September 2008. doi:10.1136/bjsm.2008.053512
British Journal of Sports Medicine 2008;42:862-863
Copyright © 2008 BMJ Publishing Group Ltd & British Association of Sport and Exercise Medicine.

Editorials

Are "exercise pills" the answer to the growing problem of physical inactivity?

Stuart J Warden, Robyn K Fuchs

Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana, USA

Dr Warden, Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W. Michigan St, Indianapolis, IN, CF-326 USA; stwarden@iupui.edu

Accepted 10 September 2008

The first 150 words of the full text of this article appear below.

Physical inactivity is an important and growing major health concern and is defined as not engaging in any regular pattern of physical activity beyond that associated with daily functioning.1 The many consequences of inactivity include reductions in insulin sensitivity of skeletal muscle and expansion of fat storage, factors associated with the development of obesity, metabolic syndrome and type 2 diabetes.2 Exercise is often performed with the goal of counteracting these changes and enhancing health and life expectancy. Imagine if the health benefits of exercise could be produced simply by taking a so-called "exercise pill". This would be every couch potato’s dream and may be a reality if a paper recently published in the prestigious journal Cell is any indication.


DISCOVERING THE "MAGIC BULLET"?

Narkar et al3 investigated the benefits of two orally active compounds on exercise endurance in mice. The first compound, known simply as GW1516, did not enhance endurance when given to . . . [Full text of this article]


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