British Journal of Sports Medicine 2008;42:862-863
Editorials
Are "exercise pills" the answer to the growing problem of physical inactivity?
Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana, USA
Dr Warden, Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W. Michigan St, Indianapolis, IN, CF-326 USA; stwarden@iupui.edu
Accepted 10 September 2008
| The first 150 words of the full text of this article appear below. |
Physical inactivity is an important and growing major health concern and is defined as not engaging in any regular pattern of physical activity beyond that associated with daily functioning.1 The many consequences of inactivity include reductions in insulin sensitivity of skeletal muscle and expansion of fat storage, factors associated with the development of obesity, metabolic syndrome and type 2 diabetes.2 Exercise is often performed with the goal of counteracting these changes and enhancing health and life expectancy. Imagine if the health benefits of exercise could be produced simply by taking a so-called "exercise pill". This would be every couch potatos dream and may be a reality if a paper recently published in the prestigious journal Cell is any indication.
DISCOVERING THE "MAGIC BULLET"?
Narkar et al3 investigated the benefits of two orally active compounds on exercise endurance in mice. The first compound, known simply as GW1516, did not enhance endurance when given to
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