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Commentary 1 on "Effects of acute prednisolone administration on exercise endurance and metabolism"

Correspondence to:
Michel Audran, Laboratoire de Biophysique et Bioanalyse, Faculte de Pharmacie, Montpellier, France; michel.audran@univ-montp1.fr

Effects of acute prednisolone administration on exercise endurance and metabolism

The first 100% of the full text of this article appears below.

Synthetic glucocorticoids are frequently used in sports because of their potent anti-inflammatory and analgesic effects. These drugs have many side effects, particularly glucocorticoid-induced adrenal insufficiency. This pharmacological class is banned by the World Andidoping Agency after systemic administration, but in competition only. For many years there has been a debate about maintaining these substances on the prohibited list. To be included on the list a substance should meet any two of the following three criteria: evidence that the substance improves athletic performance; evidence that the substance represents a health risk for the athlete; and the use of the substance violates the spirit of sports. Until now only the second criterion, the risk to health, has been clearly recognised. To date there have been few studies about the effects of glucocorticoids on athletic performance. This paper could help to clarify the situation.

Relevant Article

Effects of acute prednisolone administration on exercise endurance and metabolism

A Arlettaz, K Collomp, H Portier, A-M Lecoq, N Rieth, B Le Panse, and J De Ceaurriz
Br. J. Sports Med. 2008 42: 250-254. [Abstract] [Full Text] [PDF]