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Commentary on "Fast and slow myosins as markers of muscle injury"

Correspondence to:
Alicia Megias, Universidad Complutense, Madrid, Spain; amegias@solea.quim.ucm.es

Fast and slow myosins as markers of muscle injury

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The detection and diagnosis of muscle lesions in sportsmen and sportswomen is usually performed by medical examination, imaging techniques and laboratory tests for blood analysis. Imaging techniques are excellent for detecting and confirming grade II and grade III lesions but they give ambiguous results in some cases of grade I lesions. On the other hand, laboratory tests for blood analysis routinely determine creatine kinase and myoglobin as markers for injury. However, the cytosolic proteins do not necessarily reflect the amount of structural damage suffered by the muscle fibre. Hence, the potential of structurally-bound proteins as markers of muscle damage needs to be investigated. The authors show that fast and slow myosins are good markers for muscle lesions; in addition to their muscle fibre specificity, favourable time course for muscle release and stability in blood, serum levels of fast myosin provide a very sensitive marker for grade I lesions.

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Fast and slow myosins as markers of muscle injury

M Guerrero, M Guiu-Comadevall, J A Cadefau, J Parra, R Balius, A Estruch, G Rodas, J L Bedini, and R Cussó
Br. J. Sports Med. 2008 42: 581-584. [Abstract] [Full Text] [PDF]