SportsMedUpdate
SportsMedUpdate
University of Cape Town, South Africa
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Petersen AH, Kohler G, Korsatko S, et al. Br?J?Clin Pharmacol 2007;65:165–71.
Inhaled human insulin is a new alternative to administration by subcutaneous injection. However, the absorption of inhaled insulin may be affected by exercise — this information is important for the diabetic athlete
Does moderate exercise increase the absorption of inhaled insulin?
Subjects: 12 non-smoking healthy subjects (22.7–36.4 years)
Experimental procedure: All the subjects were screened and then underwent three interventions after inhaling 3.5 mg human insulin via a nebuliser in a random order as follows: no exercise (Con), 30 min exercise (50% VO2max) immediately after inhalation (ExImm), or 30 min exercise starting 30 min after inhalation (Ex30). The study was carried out as a 10 h euglycaemic glucose clamp (5.0 mmol/litre)
Main measures of outcome: Absorption of insulin in first 2 h (% increase from Con), insulin concentration
Insulin administration by inhalation (nebuliser) either
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