British Journal of Sports Medicine 2006;40:719-722
SHORT REPORT
Mobilisation of mesenchymal cells into blood in response to skeletal muscle injury
1 Servicio de Oncohematología y Trasplante, Hospital Universitario Niño Jesús, Madrid, Spain
2 Universidad Europea de Madrid
3 Department of Exercise and Sport Science, University of Wisconsin-La Crosse, La Crosse, WI, USA
4 Centre d’Investigacions en Bioquímica y Biología Molecular (CIBBIM), Hospital Universitari Vall d’He, Barcelona, Spain
5 Centro de Investigación, Hospital Universitario 12 de Octubre, Madrid
Correspondence to:
Dr García Castro
Servicio de Oncohematología y Transplante, Hospital Universitario Niño Jesús, Avda Menéndez Pelayo 65, 28009 Madrid, Spain; jgarciac.hnjs{at}salud.madrid.org
Mesenchymal cells recruited to damaged tissues must circulate through the bloodstream. The absolute numbers of circulating mesenchymal stem cells (cMSCs) in two different models of acute and chronic skeletal muscle injury were determined. cMSCs were present in significantly higher numbers in both models than in healthy controls. These results support the hypothesis that MSCs are mobilised into the bloodstream after skeletal muscle tissue damage. These two models (acute and chronic) would be of value in the search for molecular mediators of mobilisation of MSCs into the circulation.
Abbreviations: cMSC, circulating mesenchymal stem cell; MSC, mesenchymal stem cell; TnI-c, cardiac isoform of troponin I
Keywords: McArdle’s disease; flow cytomery; mesenchymal stem cells; mobilisation; muscle damage
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