ORIGINAL ARTICLE

Effects of acute salbutamol intake during supramaximal exercise in women

Bénédicte Le Panse¹, Alexandre Arlettaz¹, Hugues Portier¹, Anne-Marie Lecoq², Jacques De Ceaurriz³, Katia Collomp⁴

¹ LAPSEP, Orléans, France
² Unité de physiopathologie de l’Exercice, LAPSEP, Orléans, France
³ Département des analyses, AFLD, Orléans, France
⁴ LAPSEP, Département des Analyses, AFLD, Orléans, France

Correspondence to:
Professor K Collomp
LAPSEP, Département des Analyses, AFLD, Orléans, France; katia.collomp{at}univ-orleans.fr

Objective: To study the effects of an acute therapeutic oral intake of ß₂ agonist on performance and substrate response during supramaximal exercise in women.

Methods: 12 healthy moderately trained female volunteers performed a Wingate test after ingestion of placebo (Pla) and salbutamol (Sal; 4 mg) according to a double-blind randomised crossover study. Blood samples were collected at rest, at the end of exercise and after 5 (r5), 10 (r10) and 15 (r15) min of passive recovery for adrenocorticotropic hormone (ACTH), growth hormone (GH), insulin, blood glucose and lactate measurements.

Results: Peak power (PP) and mean power (MP) significantly increased whereas time to peak power was significantly shorter with Sal than with Pla (p<0.05). No change was observed in the fatigue index. ACTH was not significantly modified but r15 growth hormone significantly decreased (p<0.05) after the intake of Sal. Both blood INS and blood glucose were significantly increased by the intake of Sal during all the experiments (p<0.01). Blood lactate was significantly increased by the intake of Sal compared with that of Pla (p<0.05) after 10 and 15 min of passive recovery.

Conclusion: From these data, acute therapeutic oral intake of Sal seems to induce, irrespective of the subjects’ gender, an improvement in performance during a supramaximal exercise—that is, increase in PP and MP. Further studies are necessary to clarify whether the mechanisms involved in the response to intake of Sal are linked to central and/or peripheral pathways.

Abbreviations: ANOVA, analysis of variance; ACTH, adrenocorticotropic hormone; EIB, exercise-induced bronchoconstriction; GH, growth hormone; Glu, glucose; Ins, insulin; Lac, lactate; MP, mean power; OC, oral contraceptive; Pla, placebo; PP, peak power; Sal, salbutamol; TTPP, time to peak power

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