Short-term salbutamol ingestion and supramaximal exercise in healthy women

Bénédicte LE PANSE ¹, Alexandre ARLETTAZ ¹, Hugues PORTIER ¹, Anne-Marie LECOQ ¹, Jacques DE CEAURRIZ ² and Katia COLLOMP ^3*

¹ LAPSEP, Service de Physiopathologie de l'exercice, France
² LNDD, France
³ LAPSEP Service de Physiopathologie de l'exercice, LNDD, France

^* To whom correspondence should be addressed. E-mail: katia.collomp{at}univ-orleans.fr.

Accepted 23 April 2006

Abstract

Objective: To test the hypothesis that chronic salbutamol intake improves performance during a supramaximal exercise and to estimate the repercussions of this treatment on body composition, bone mass and metabolic indices in healthy women.

Methods: A total of 14 female (7 sedentary and 7 seven recreational trained) volunteers performed a 30s Wingate test with and without salbutamol (SAL, 12 mg/day during 4 weeks) ingestion in a random, double blind, crossover design. Blood samples were collected both at rest, at the end of the test and during passive recovery for lactate measurements. Body composition and bone mass were determined by dual energy X-ray absorptiometry.

Results: Peak power appeared significantly earlier and was significantly increased (p<0.05) after SAL intake in all subjects. There was no change in total work performed and in fatigue indices with SAL compared to placebo (PLA). No significant alteration in lean or in fat body mass and in bone parameters were observed with SAL treatment in either group during the trial. In contrast, blood lactate was significantly increased during the recovery (p<0.05) after SAL vs PLA.

Conclusion: As in men, chronic administration of therapeutic levels of salbutamol did not induce an anabolic effect in women but increased maximal anaerobic power. Further studies are necessary to clarify the mechanisms involved.

Key Words: albuterol, body composition, chronic intake, performance, woman

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