Immunoglobulin responses to a repeated bout of downhill running

Andrew J McKune ^1*, Lucille L Smith ¹, Stuart J Semple ¹, Barbara Mokethwa ² and Ahmed A Wadee ²

¹ Tshwane University of Technology, South Africa
² University of the Witwatersrand, South Africa

^* To whom correspondence should be addressed. E-mail: mckuneaj{at}tut.ac.za.

Accepted 30 July 2006

Abstract

The present study examined the effect of downhill running on immunoglobulin (Ig) responses. Eleven untrained males performed 2 X 60 min bouts of downhill running (-13.5% gradient), at a speed eliciting 75% of their VO2peak on a level grade. Runs were spaced 14 d apart (RUN1, RUN2). Serum samples were collected before, after, and every hour for 12 h and every 24 h for 6 d. Serum total creatine kinase (CK), Ig isotypes and subclasses were measured and results were analyzed using a repeated measures ANOVA (12 h period: 2 X 14; 24 h intervals 2 X 6, p iü.05). There was a significant interaction effect for CK (levels lower after RUN2 vs RUN1, 6 h C 24 h) and exercise effect, with the serum concentrations of IgG1, IgG2, IgG4 and IgE lower, and IgM higher, after RUN2. Lower levels of IgG1, IgG2, and IgE after RUN2 may reflect a dampened auto-immune inflammatory response to auto-antigens and enhanced auto-antigen clearance mediated by the up-regulation of IgM.

Key Words: antibody, auto-antigens, eccentric, immunoglobulin, inflammation

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