Br J Sports Med. Published Online First: 28 June 2006. doi:10.1136/bjsm.2006.028639
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Mobilisation of mesenchymal cells into blood in response to skeletal muscle injury
1 Servicio de Oncohematología y Trasplante, Hospital Universitario Niño Jesús, Spain
2 Universidad Europea de Madrid, Spain
3 Department of Exercise and Sport Science, University of Wisconsin-La Crosse, United States
4 Centre d'Investigacions en Bioquímica y Biología Molecular (CIBBIM), Spain
5 Centro de Investigación, Hospital Universitario 12 de Octubre, Spain
* To whom correspondence should be addressed. E-mail: alejandro.lucia{at}uem.es.
Accepted 13 June 2006
Abstract
Mesenchymal cells recruited to damaged tissues must circulate through the bloodstream. We determined the absolute numbers of circulating mesenchymal cells (cMSCs) in two different models of acute and chronic skeletal muscle injury. We found that cMSCs were present in significantly higher numbers in both models, when compared to healthy controls. Our results support the hypothesis that MSCs mobilise into blood following skeletal muscle tissue damage. These two models (acute and chronic) would be of value in the search for molecular mediators of mobilisation of mesenchymal cells into the circulation.
Key Words: McArdle's disease, flow cytometry, mesenchymal stem cells, mobilisation, muscle damage
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