CKMM Gene Polymorphism and Running Economy responses to a 18-week 5000 m training program

Zhou Duoqi ¹, Yang Hu ^2*, Gang Liu ², Li Gong ³, Yi Xi ⁴ and Li Wen ⁴

¹ Anqing University and Beijing Sports University, China
² Beijing Sport University, China
³ Anqing University, China
⁴ Tianjin Institute of Physical Education, China

^* To whom correspondence should be addressed. E-mail: hyyr1{at}163.com.

Accepted 11 September 2006

Abstract

Objectives: The purpose of this study was to investigate the association between CKMM (muscle- specific creatine kinase) gene polymorphism and the effects of endurance training on running economy.

Methods: 102 biologically unrelated male recruitments from Northern China performed a 5000 m running program, with an intensity of 95-105% ventilatory threshold (VT). The protocol was 3 times per week and lasted for 18 weeks. Running economy (RE) indexes were determined by having the subjects run on a treadmill before and after the protocol, and the A/G polymorphism in 3' untranslated region of CKMM was detected by PCR-RFLP (NcoI restriction enzyme).

Results: Three expected genotypes for CKMM-NcoI (AA, AG and GG) were observed in the subjects. After training, all RE indexes declined markedly. Moreover, VO_2RE,VO_2RE/w,VO_2RE/lbw VE_RE in AG groups were larger than those in AA and GG groups. Conclusions: The findings as noted above indicated that the CKMM gene polymorphism might contribute to individual RE responses to endurance training.

Key Words: CKMM gene polymorphism, Endurance training, running economy

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Lippi, G., Longo, U. G., Maffulli, N. (2009). Genetics and sports. Br Med Bull 0: ldp007v1-21 [Abstract] [Full Text]  
• Heled, Y., Bloom, M. S., Wu, T. J., Stephens, Q., Deuster, P. A. (2007). CM-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise. J. Appl. Physiol. 103: 504-510 [Abstract] [Full Text]