Br J Sports Med. Published Online First: 24 October 2006. doi:10.1136/bjsm.2006.030643
Tendinopathies issue |
Tissue engineering for tendon repair
1 Institute of Science and Technology in Medicine, Keele University, United Kingdom
2 Keele University School of Medicine, United Kingdom
* To whom correspondence should be addressed. E-mail: osa14{at}keele.ac.uk.
Accepted 22 September 2006
Abstract
Tissue engineering aims to induce tissue self- regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, the generation of a uniaxially orientated collagen type I matrix is required. Biochemical and physical factors can potentially alter both the production and the organization of this matrix, and their combination in a dose and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocytes growth in three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.
Key Words: growth factors, mechanical stimuli, scaffolds, tendon tissue engineering, tenocytes
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