Can McArdle patients run? A case report

Margarita Pérez ¹, Maria Moran ², Claudia Cardona ¹, José L Maté-Muñoz ¹, Juan C Rubio ³, Antoni L Andreu ², Miguel A Martin ³, Joaquín Arenas ³ and Alejandro Lucia ^1*

¹ Universidad Europea de Madrid, Spain
² Hospital Universitari Val d'Hebron, Spain
³ Hospital Universitario 12 de Octubre, Spain

^* To whom correspondence should be addressed. E-mail: alejandro.lucia{at}uem.es.

Accepted 18 September 2006

Abstract

Patients with McArdle disease commonly adopt a sedentary lifestyle. This sedentary behaviour, however, usually worsens the limited exercise capacity of these patients. Although eccentric muscle work can be associated with rhabdomyolysis, supervised eccentric training with gradually increasing loads has important advantages compared to conventional concentric work, particularly for patients with poor cardiorespiratory capacity. We report the beneficial effects in a 38-year old patient (particularly, increased VO2peak (from 14.6 to 30.8 ml/kg/min) and increased gross muscle efficiency (from 13.8 to 17.2%)) induced by a supervised aerobic training program of 7-month duration including 3-4 weekly running sessions (up to 60 min/session). These preliminary data suggest the potential therapeutic value of this type of exercise in these patients.

Key Words: eccentric contraction, glycogenosis type V, muscle phosphorylase, rhabdomyolysis, training

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Gomez-Gallego, F, Santiago, C, Moran, M, Perez, M, Mate-Munoz, J L, del Valle, M F., Rubio, J C, Garcia-Consuegra, I, Foster, C, Andreu, I A L, Martin, M A, Arenas, J, Lucia, A (2008). The I allele of the ACE gene is associated with improved exercise capacity in women with McArdle disease. Br. J. Sports. Med. 42: 134-140 [Abstract] [Full Text]  
• Perez, M., Mate-Munoz, J. L., Foster, C., Rubio, J. C., Andreu, A. L., Martin, M. A., Arenas, J., Lucia, A. (2007). Exercise Capacity in a Child With McArdle Disease. J Child Neurol 22: 880-882 [Abstract]