The effect of conditioning to severe exercise upon serum immunoreactive insulin levels (IRI) and serum glucose concentrations (GC) was studied in active and sedentary groups of middle-aged men. The responses of serum IRI and serum GC were determined during graded cycle ergometer exercise which required similar low and high relative work intensities, before (pre) and after (post) a four month physical fitness programme. Both groups demonstrated a marked decline in serum IRI during high intensity exercise from pre to post tests, and a tendency to maintain serum, GC (sedentary group) or elevate serum GC (active group) during exercise, following the conditioning programme. The data provides evidence of a bi-directional response of serum IRI and serum GC to graded exercise, with only minor modifications in the response patterns resulting from exercise conditioning.
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