Fibrinogen can be considered as a major cardiovascular risk factor. Therefore there is a growing interest in methods to lower its plasma level. This paper is aimed at reviewing the data investigating the effects of regular exercise on plasma fibrinogen levels. Cross-sectional studies strongly suggest that regular exercise will reduce fibrinogen levels, and longitudinal data confirm this. The average decrease achieved by regular endurance exercise over several months is around 0.4 g/l. It can be extrapolated that this corresponds to a substantial decrease in risk of coronary heart disease. It is concluded that regular exercise is the most practicable approach known to date to lower plasma fibrinogen levels.
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