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Br J Sports Med 2000;34:289-292 doi:10.1136/bjsm.34.4.289
  • Original article

Factor XIIa and triacylglycerol rich lipoproteins: responses to exercise intervention

  1. K Woolf-May1,
  2. W Jones2,
  3. E M Kearney3,
  4. R C R Davison1,
  5. S Bird1
  1. 1Department of Sport and Exercise Science, Canterbury Christ Church University College, Canterbury CT1 1QU, United Kingdom
  2. 2Haemophilia Centre, Kent and Canterbury Hospital, Canterbury CT1 3NG
  3. 3Department of Pathology, Queen Elizabeth the Queen Mother Hospital, Margate, Canterbury CT9 4AN
  1. Correspondence to: S Bird, Department of Sport and Exercise Science, Canterbury Christ Church University College, North Holmes Road, Canterbury, Kent CT1 1QU, United Kingdom email: s.r.bird{at}cant.ac.uk
  • Accepted 22 February 2000

Abstract

Objectives—(a) To determine if factor XIIa (FXIIa) would be sensitive to change from exercise intervention in a group of previously sedentary/low active middle aged men and women; (b) to investigate further the previously reported relation between FXIIa and triacylglycerol (TAG) rich lipoproteins.

Methods—Thirty seven men (mean (SD) age 57 (7) years) and 60 women (mean age 54 (7) years) completed the study. Before the intervention, these subjects were randomly allocated to a group of walkers (n = 81) or controls (n = 16). Before and after an 18 week walking intervention, fasted blood samples were collected and analysed for FXIIa, TAG, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and apolipoprotein (apo) B.

Results—Kruskal-Wallis analysis of data obtained before the intervention showed no significant differences (p>0.4) between the walking and control groups for age, height, body mass, gender, FXIIa, TAG, TC, HDL-C, or apo B, although the women did show significantly lower levels of TAG (p<0.04) and higher HDL-C (p<0.0001) than the men. General linear model analysis of data obtained after the intervention, using the baseline value as a covariate, showed significant reductions (p<0.0001) in FXIIa for the walkers compared with the controls. Pearson product-moment correlations also showed significant relations between the concentrations of FXIIa and TAG, TC, LDL-C, and apo B.

Conclusions—The findings of this study suggest that FXIIa is sensitive to change from exercise intervention and support previous research showing an association between the concentrations of FXIIa and TAG rich lipoproteins.

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