RELATION OF HEIGHT, BODY MASS, ENERGY INTAKE, AND PHYSICAL ACTIVITY TO RISK OF RENAL CELL CARCINOMA: RESULTS FROM THE NETHERLANDS COHORT STUDY

Background: The risk of developing renal cell carcinoma has been associated with increased body weight, increased height, and reduced physical activity, but these parameters have not been well studied together.

Research question/s: What is the association between anthropometry, energy intake, and physical activity and the risk of developing renal cell carcinoma (RCC)?

Methodology:Subjects: 58 279 men and 62 573 women (55–69 years) completed a self-administered questionnaire at baseline.

Experimental procedure:Subjects completed a baseline questionnaire including current and past weight, height, energy intake, and physical activity (leisure and occupational). After 9.3 years of follow up, 275 microscopically confirmed incident cases of RCC were available for analysis.

Measures of outcome: Incidence rate ratios for RCC were estimated using Cox proportional hazards models.

Main finding/s:

• Height was associated with RCC risk only in women (per 5 cm increment, rate ratio (RR)  =  1.23, 95% confidence interval (CI): 1.03 to 1.46)

• Body mass index (weight (kg)/height (m)²) was associated with increased risk of RCC (per 1-kg/m² increment, RR  =  1.07, 95% CI: 1.02 to 1.12) for men and women, as was gain in body mass index from age 20 years to baseline (per 1-kg/m² increment, RR  =  1.06, 95% CI: 1.01 to 1.10)

Conclusion/s:

• An increased body mass index and a gain in body mass index since the age of 20 years are associated with an increased risk of developing …