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TOPICAL KETOPROFEN PATCH (100 MG) FOR THE TREATMENT OF ANKLE SPRAIN. a RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED STUDY
Professor Martin P Schwellnus, University of Cape Town, South Africa
Background: The use of a topical non-steroidal anti-inflammatory drug to treat soft tissue injuries in athletes may be advantageous because it may reduce the risk of side effects; however, their efficacy needs to be established.
Research question/s: Does the application of a topical non-steroidal anti-inflammatory drug (100 mg patch of ketoprofen) applied once a day for 7 days, reduce pain in patients with an acute ankle sprain?
Methodology:Subjects: 163 patients with an acute ankle sprain (grade I or II).
Experimental procedure: Subjects suffering from a painful (pain >50 mm on a 0–100 mm VAS), recent (<2 days) ankle sprain were randomised into two treatment groups: (1) a ketoprofen group (100 mg topical patch 1/day for 7 days, KETO = 81, and 2) a placebo group, CON = 82). Patients were followed on days 0, 3 or 4, 7, and 14
Measures of outcome: Pain (on VAS 0–100) in the past 24 hrs, pain on active motion, a disability rating (0–4) and ankle swelling (circumference at malleolar level), rescue medication use, adverse events.
There was significantly less disability, greater total pain relief, less ankle swelling in the KETO compared …
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