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Microwave hyperthermia treatment increases heat shock proteins in human skeletal muscle
  1. Yuji Ogura1,
  2. Hisashi Naito2,
  3. Toshihiro Tsurukawa3,
  4. Noriko Ichinoseki-Sekine1,
  5. Norio Saga2,
  6. Takao Sugiura4,
  7. Shizuo Katamoto2
  1. 1Institute of Health and Sports Science & Medicine, Juntendo University, Inba, Japan
  2. 2Graduate School of Health and Sports Science, Juntendo University, Inba, Japan
  3. 3Department of Rehabilitation Medicine, Saitama Medical School, Iruma, Japan
  4. 4Faculty of Education, Yamaguchi University, Yamaguchi, Japan
  1. Correspondence to:
 Y Ogura
 Institute of Health and Sports Science & Medicine, Juntendo University, 1-1 Hiragagakuendai, Inba, Chiba, 270-1695, Japan; yuji-ogura{at}sakura.juntendo.ac.jp

Abstract

Objective: To test the hypothesis that microwave hyperthermia treatment (MHT) increases heat shock proteins (HSPs) in the human vastus lateralis muscle.

Methods: Four untrained healthy male volunteers participated in this study. The lateral side of the thigh of one leg (heated leg) was heated with a microwave generator (2.5 GHz, 150 W) for 20 min. At 1 day after the MHT, a muscle sample was taken from the heated leg. A control sample was taken from the unheated leg on another day of the MHT. For both legs, HSP90, HSP72 and HSP27 levels were compared.

Results: The HSP90, HSP72 and HSP27 levels in heated legs were significantly higher than those in control legs (p<0.05).

Conclusions: Application of MHT can increase the levels of several HSPs in human skeletal muscle.

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Footnotes

  • Funding: Our research was partly supported by grants from Juntendo University and a Grant-in-Aid for Scientific Research (16300212 and 12480011 to HN) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

  • Competing interests: None declared.

  • Published Online First 15 January 2007

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