Article Text

PDF
Tissue engineering for tendon repair
  1. Pierre-Olivier Bagnaninchi1,
  2. Ying Yang1,
  3. Alicia J El Haj1,
  4. Nicola Maffulli2
  1. 1Institute of Science and Technology in Medicine, Keele University, Hartshill, UK
  2. 2Keele University School of Medicine, Hartshill, UK
  1. Correspondence to:
 N Maffulli
 Keele University School of Medicine, Hartshill, UK;osa14{at}keele.ac.uk

Abstract

Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, a uniaxially orientated collagen type I matrix has to be generated. Biochemical and physical factors can potentially alter both the production and the organisation of this matrix, and their combination in a dose- and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocyte growth in a three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.

  • bFGF, basic fibroblast growth factor
  • BMP, bone morphogenetic protein
  • ECM, extracellular matrix
  • MMP, matrix metalloproteinase
  • MSC, mesenchymal stem cell
  • PDGF, platelet-derived growth factor

Statistics from Altmetric.com

Footnotes

  • Published Online First 24 October 2006

  • Competing interests: None declared.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.