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Br J Sports Med 2007;41:e10 doi:10.1136/bjsm.2006.030643
  • Electronic pages

Tissue engineering for tendon repair

  1. Pierre-Olivier Bagnaninchi1,
  2. Ying Yang1,
  3. Alicia J El Haj1,
  4. Nicola Maffulli2
  1. 1Institute of Science and Technology in Medicine, Keele University, Hartshill, UK
  2. 2Keele University School of Medicine, Hartshill, UK
  1. Correspondence to:
 N Maffulli
 Keele University School of Medicine, Hartshill, UK;osa14{at}keele.ac.uk
  • Accepted 22 September 2006
  • Published Online First 24 October 2006

Abstract

Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, a uniaxially orientated collagen type I matrix has to be generated. Biochemical and physical factors can potentially alter both the production and the organisation of this matrix, and their combination in a dose- and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocyte growth in a three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.

Footnotes

  • Published Online First 24 October 2006

  • Competing interests: None declared.

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