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Marqueti RC, Parizotto NA, Chriguer RS, et al. Am J Sports Med 2006;34:1274–80
Anabolic-androgenic steroids (AAS), despite being on the banned list, are still used by athletes to enhance performance; however, AAS have been shown to have some negative effects on the Achilles tendon.
Do AAS, combined with an exercise programme, alter tendon remodelling in rats?
40 Wistar rats.
Rats were randomised and then grouped: sedentary (SED = 10), anabolic-androgenic steroids (AAS = 10; 5 mg/kg subcutaneously weekly), exercise training (EX = 10; 4 × 10 jumps each, overload of 50–70% of BW for 6 weeks) and AAS with training (AAS+EX). Following sacrifice, histology, gelatin zymography and serum corticosterone were measured. Activity of matrix metallopeptidases, a marker for tendon remodelling, was analysed in tissue extracts by zymography.
Measures of outcome:
Matrix metallopeptidase activity, inflammatory infiltrate, fibrosis, serum corticosterone.
Histology: In the EX group, the most external layer that covers the tendon was thicker with aggregation of the collagen fibres, suggesting an increase in collagen synthesis, whereas in the AAS+EX group, an inflammatory infiltrate and fibrosis in tendons was observed as well as an increase of the serum corticosterone level.
was observed Exercise training upregulated matrix …
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