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Mobilisation of mesenchymal cells in cardiac patients: is intense exercise necessary?
  1. A Lucia1,
  2. A De La Rosa2,
  3. M Avila Silván1,
  4. L M López-Mojares1,
  5. A Boraita3,
  6. M Pérez1,
  7. C Foster4,
  8. J García-Castro5,
  9. M Ramirez6
  1. 1
    Universidad Europea de Madrid, Spain
  2. 2
    Hospital Universitario La Laguna, Spain
  3. 3
    Consejo Superior de Deportes, Madrid, Spain
  4. 4
    University of Wisconsin-La Crosse, USA
  5. 5
    Centro andaluz de Células Madre, Granada, Spain
  6. 6
    Hospital Infantil Universitario Niño Jesús, Madrid, Spain
  1. Alejandro Lucia, MD PhD, Universidad Europea de Madrid, 28670 Villaviciosa de Odón; alejandro.lucia{at}uem.es

Abstract

Circulating mesenchymal cells (cMCs) have a potential for regenerating damaged tissue, e.g., ischaemic myocardium. In patients (age range: 53–76 years) with stable coronary artery disease cMCs were determined before and after dynamic exercise of moderate (< respiratory compensation threshold (RCT)) (n = 9 patients) or high intensity (>RCT) (n = 11). Only high-intensity exercise (i.e., provoking signs of myocardial ischaemia in 3 patients and ventricular extrasystoles in another) induced a significant increase in cMCs (p = 0.009). These results support the hypothesis that intense exercise (near or at the point of myocardial ischaemia) is a potent stimulus for MC mobilisation.

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Footnotes

  • Competing interests: None.

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