Article Text

PDF
SportsMedUpdate
  1. Martin P Schwellnus
  1. Department of Human Biology, University of Cape Town, Cape Town, South Africa

Statistics from Altmetric.com

In an animal model of an anterior cruciate ligament (ACL) injury, the application of a collagen-platelet composite (CPC) at the time of ACL reconstruction improved structural properties of the graft and reduced early antero-posterior knee laxity at 15 weeks after surgery.

Collagen–platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model

Background

The outcome of ACL reconstruction is variable, and many patients have increased joint laxity postoperatively.

Research question/s

Does the placement of a CPC around the graft at the time of ACL reconstruction decrease postoperative knee laxity and improve the structural properties of the graft?

Methodology

Animal material: Thirteen immature pigs that underwent unilateral ACL reconstruction with a bone–patellar tendon–bone allograft following ACL resection.

Experimental procedure: The animals were randomly assigned to a standard allograft (CON=6) or an allograft where a CPC was placed around the allograft (CPC=7). Animals were killed after 15 weeks and assessed clinically: AP laxity, structural properties (yield load, maximum load to failure, stiffness) and qualitative histology.

Measures of outcome: Yield load, maximum load, stiffness (all as a percentage of reconstructed to intact side), histology.

Main finding/s

  • ▶. AP laxity: In the CPC group, there was a significant reduction in AP laxity (reconstructed knees, normalised to the contra-lateral), 60° and 90° of knee flexion compared with the CON group, p<0.001.

  • ▶. Histology: Cellular and vessel infiltration were observed in both the CON and CPC groups; regions of necrosis were present only in the CON group.

Conclusion/s

In an animal model of an ACL injury, the application of a CPC at the time of …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.