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The effect of exercise on innate mucosal immunity
  1. N P West1,2,
  2. D B Pyne1,3,
  3. J M Kyd4,
  4. G M Renshaw2,
  5. P A Fricker5,
  6. A W Cripps6
  1. 1Department of Physiology, Australian Institute of Sport, Canberra, Australia
  2. 2School of Physiotherapy and Exercise Science, Griffith Health, Griffith University, Gold Coast, Australia
  3. 3School of Medicine, Australian National University, Canberra, Australia
  4. 4School of Health Services, Central Queensland University, Rockhampton, Australia
  5. 5Executive, Australian Institute of Sport, Canberra, Australia
  6. 6Griffith Health, Griffith University, Gold Coast, Australia
  1. Correspondence to Professor A W Cripps, Griffith Health, Griffith University, Gold Coast Campus, Griffith University 4222, Queensland, Australia; allan.cripps{at}griffith.edu.au

Abstract

Methods The authors conducted a prospective observational study comparing salivary lactoferrin and lysozyme concentration over 5 months (chronic changes) in elite rowers (n=17, mean age 24.3±4.0 years) with sedentary individuals (controls) (n=18, mean age=27.2±7.1 years) and a graded exercise test to exhaustion (acute changes) with a cohort of elite rowers (n=11, mean age 24.7±4.1).

Results Magnitudes of differences and changes were interpreted as a standardised (Cohen's) effect size (ES). Lactoferrin concentration in the observational study was approximately 60% lower in rowers than control subjects at baseline (7.9±1.2 µg/ml mean±SEM, 19.4±5.6 µg/ml, p=0.05, ES=0.68, ‘moderate’) and at the midpoint of the season (6.4±1.4 µg/ml mean ± SEM, 21.5±4.2 µg/ml, p=0.001, ES=0.89, ‘moderate’). The concentration of lactoferrin at the end of the study was not statistically significant (p=0.1) between the groups. There was no significant difference between rowers and control subjects in lysozyme concentration during the study. There was a 50% increase in the concentration of lactoferrin (p=0.05, ES=1.04, ‘moderate’) and a 55% increase in lysozyme (p=0.01, ES=3.0, ‘very large’) from pre-exercise to exhaustion in the graded exercise session.

Conclusion Lower concentrations of these proteins may be indicative of an impairment of innate protection of the upper respiratory tract. Increased salivary lactoferrin and lysozyme concentration following exhaustive exercise may be due to a transient activation response that increases protection in the immediate postexercise period.

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Footnotes

  • Ethics approval Ethics approval was provided by the Griffith University Human Research Ethics Committee and the AIS Ethics Committee.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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