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Electrocardiographic interpretation in athletes: the ‘Seattle Criteria’
  1. Jonathan A Drezner1,
  2. Michael John Ackerman2,
  3. Jeffrey Anderson3,
  4. Euan Ashley4,
  5. Chad A Asplund5,
  6. Aaron L Baggish6,
  7. Mats Börjesson7,
  8. Bryan C Cannon8,
  9. Domenico Corrado9,
  10. John P DiFiori10,
  11. Peter Fischbach11,
  12. Victor Froelicher4,
  13. Kimberly G Harmon1,
  14. Hein Heidbuchel12,
  15. Joseph Marek13,
  16. David S Owens14,
  17. Stephen Paul15,
  18. Antonio Pelliccia16,
  19. Jordan M Prutkin14,
  20. Jack C Salerno17,
  21. Christian M Schmied18,
  22. Sanjay Sharma19,
  23. Ricardo Stein20,
  24. Victoria L Vetter21,
  25. Mathew G Wilson22
  1. 1Department of Family Medicine, University of Washington, Seattle, Washington, USA
  2. 2Departments of Medicine, Pediatrics, and Molecular Pharmacology & Experimental Therapeutics, Divisions of Cardiovascular Diseases and Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota, USA
  3. 3Department of Athletics, University of Connecticut, Storrs, Connecticut, USA
  4. 4Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, California, USA
  5. 5Department of Family Medicine, Eisenhower Army Medical Center, Fort Gordon, Georgia, USA
  6. 6Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
  7. 7Department of Cardiology, Swedish School of Sports and Health Sciences, Karolinska University Hospital, Stockholm, Sweden
  8. 8Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
  9. 9Department of Cardiac, Thoracic, and Vascular Sciences, University of Padua, Padova, Italy
  10. 100Division of Sports Medicine, Department of Family Medicine, University of California Los Angeles, Los Angeles, California, USA
  11. 11Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
  12. 12Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
  13. 13Midwest Heart Foundation, Oakbrook Terrace, Illinois, USA
  14. 14Division of Cardiology, University of Washington, Seattle, Washington, USA
  15. 15Department of Family and Community Medicine, University of Arizona, Tucson, Arizona, USA
  16. 16Department of Medicine, Institute of Sport Medicine and Science, Rome, Italy
  17. 17Division of Cardiology, Seattle Children's Hospital, Seattle, Washington, USA
  18. 18Division of Cardiology, Cardiovascular Centre, University Hospital Zurich, Zurich, Switzerland
  19. 19Department of Cardivascular Sciences, St George's University of London, London, UK
  20. 20Cardiology Department, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, Brazil
  21. 21Division of Cardiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
  22. 22Department of Sports Medicine, ASPETAR, Qatar Orthopedic and Sports Medicine Hospital, Doha, Qatar
  1. Correspondence to Jonathan A Drezner, Department of Family Medicine, University of Washington, 1959 NE Pacific Street, Box 356390, Seattle, Washington 98195, USA; jdrezner{at}uw.edu

Abstract

Sudden cardiac death (SCD) is the leading cause of death in athletes during sport. Whether obtained for screening or diagnostic purposes, an ECG increases the ability to detect underlying cardiovascular conditions that may increase the risk for SCD. In most countries, there is a shortage of physician expertise in the interpretation of an athlete's ECG. A critical need exists for physician education in modern ECG interpretation that distinguishes normal physiological adaptations in athletes from abnormal findings suggestive of pathology. On 13–14 February 2012, an international group of experts in sports cardiology and sports medicine convened in Seattle, Washington, to define contemporary standards for ECG interpretation in athletes. The objective of the meeting was to develop a comprehensive training resource to help physicians distinguish normal ECG alterations in athletes from abnormal ECG findings that require additional evaluation for conditions associated with SCD.

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Introduction

Cardiovascular-related sudden death is the leading cause of mortality in athletes during sport.1 ,2 The majority of disorders associated with increased risk of sudden cardiac death (SCD), such as cardiomyopathies and primary electrical diseases, are suggested by abnormal findings present on a 12-lead ECG. ECG interpretation in athletes requires careful analysis to properly distinguish physiological changes related to athletic training from findings suggestive of an underlying pathological condition. Whether used for the diagnostic evaluation of cardiovascular-related symptoms, a family history of inheritable cardiac disease or premature SCD, or for screening of asymptomatic athletes, ECG interpretation is an important skill for physicians involved in the cardiovascular care of athletes.

Distinguishing normal from abnormal

A challenge in the interpretation of an athlete's ECG is the ability to accurately differentiate findings suggestive of a potentially lethal cardiovascular disorder from benign physiological adaptations occurring as the result of regular, intense training (ie, athlete's heart). Several reports have outlined contemporary ECG criteria intended to distinguish normal ECG findings in athletes from ECG abnormalities requiring additional evaluation.3–8 Despite the publication of these consensus guidelines, most sports medicine and cardiology training programmes lack a standard educational curriculum on ECG interpretation in athletes.

The impact of standardised criteria

Studies demonstrate that without further education the ability of many physicians to accurately interpret an athlete's ECG is relatively poor and may lead to an unacceptable rate of false-positive interpretations and unnecessary secondary evaluations.9 ,10 However, providing physicians standardised criteria with which to evaluate an ECG considerably improves accuracy.10 In a study involving physicians across different specialties, use of a simple two-page criteria tool to guide ECG interpretation significantly improved accuracy to distinguish normal from abnormal findings, even in physicians with little or no experience.10 Therefore, physician education in ECG interpretation is feasible and accompanied by meaningful improvements in accuracy when a reference standard is used to assist interpretation. Further education is needed to produce a larger physician infrastructure that is skilled and capable of accurate ECG interpretation in athletes.

Summit on ECG interpretation in athletes

On 13–14 February 2012, the American Medical Society for Sports Medicine (AMSSM) co-sponsored by the FIFA Medical Assessment and Research Center (F-MARC) held a ‘Summit on Electrocardiogram Interpretation in Athletes’ in Seattle, Washington. Partnering medical societies included the European Society of Cardiology (ESC) Sports Cardiology Subsection and the Pediatric & Congenital Electrophysiology Society (PACES), as well as other leading cardiologists on ECG interpretation in athletes from the USA, Europe and around the world. The goals of the summit meeting were to:

  1. define ECG interpretation standards to help physicians distinguish normal ECG alterations in athletes from abnormal ECG findings that require additional evaluation for conditions associated with SCD;

  2. outline recommendations for the initial evaluation of ECG abnormalities suggestive of a pathological cardiovascular disorder; and

  3. assemble this information into a comprehensive resource and online training course targeted for physicians around the world to gain expertise and competence in ECG interpretation.

The consensus recommendations developed are presented in three papers:

  • 4. Normal Electrocardiographic Findings: Recognizing Physiologic Adaptations in Athletes11

  • 5. Abnormal Electrocardiographic Findings in Athletes: Recognizing Changes Suggestive of Cardiomyopathy12

  • 6. Abnormal Electrocardiographic Findings in Athletes: Recognizing Changes Suggestive of Primary Electrical Disease13

Box 1 summarises a list of normal ECG findings in athletes that are considered physiological adaptations to regular exercise and do not require further evaluation. Table 1 summarises a list of abnormal ECG findings unrelated to athletic training that may suggest the presence of a pathological cardiac disorder and should trigger additional evaluation in an athlete.

Box 1

Normal ECG findings in athletes

  1. Sinus bradycardia (≥ 30 bpm)

  2. Sinus arrhythmia

  3. Ectopic atrial rhythm

  4. Junctional escape rhythm

  5. 1° AV block (PR interval > 200 ms)

  6. Mobitz Type I (Wenckebach) 2° AV block

  7. Incomplete RBBB

  8. Isolated QRS voltage criteria for LVH

    • Except: QRS voltage criteria for LVH occurring with any non-voltage criteria for LVH such as left atrial enlargement, left axis deviation, ST segment depression, T-wave inversion or pathological Q waves

  9. Early repolarisation (ST elevation, J-point elevation, J-waves or terminal QRS slurring)

  10. Convex (‘domed’) ST segment elevation combined with T-wave inversion in leads V1–V4 in black/African athletes

These common training-related ECG alterations are physiological adaptations to regular exercise, considered normal variants in athletes and do not require further evaluation in asymptomatic athletes.

AV, atrioventricular; bpm, beats per minute; LVH, left ventricular hypertrophy; ms, milliseconds; RBBB, right bundle branch block.

Table 1

Abnormal ECG findings in athletes

Online E-learning ECG training module—FREE!

The Seattle Criteria will be used to develop a comprehensive online training module for physicians to acquire a common foundation in ECG interpretation in athletes. This state of the art E-learning resource provides additional ECG examples, figures and explanations, and is prepared in a user friendly educational format to optimise learning. This online training module is accessible at no cost to any physician world-wide at: http://learning.bmj.com/ECGathlete

Limitations of the Seattle Criteria

While the ECG increases the ability to detect underlying cardiovascular conditions that place athletes at increased risk, ECG as a diagnostic tool has limitations in both sensitivity and specificity. Even if properly interpreted, an ECG will not detect all conditions predisposing to SCD. In addition, the true prevalence of specific ECG parameters in athletes and in diseases that predispose to SCD is often unknown and requires further study. The Seattle Criteria were developed with thoughtful attention to balance sensitivity (disease detection) and specificity (false-positives), while maintaining a clear and usable checklist of findings to guide ECG interpretation for physicians, including new learners.

The criteria define ECG findings that warrant further cardiovascular evaluation for disorders that predispose to SCD. The criteria were developed with consideration of ECG interpretation in the context of an asymptomatic athlete age 14–35. An athlete is defined as an individual who engages in regular exercise or training for sport or general physical fitness, typically with a goal of improving performance. In the presence of personal cardiac symptoms or a family history that is positive for genetic cardiovascular disease or premature SCD, the criteria may require modification. Physicians also may choose to deviate from consensus standards based on their experience or practice setting.

The evaluation of ECG abnormalities is performed ideally in consultation with a specialist with knowledge and experience in athlete's heart and disorders associated with SCD in young athletes. As new scientific data become available, revision of the criteria may further improve the accuracy of ECG interpretation within the athletic population.

Conclusions

Prevention of SCD in athletes remains a highly visible topic in sports medicine and cardiology. Cardiac adaptation and remodelling from regular athletic training produces common ECG alterations that could be mistaken as abnormal. Whether performed for screening or diagnostic purposes as part of the cardiac evaluation in athletes, it is critical that physicians responsible for the cardiovascular care of athletes be guided by ECG interpretation standards that improve disease detection and limit false-positive results. The ECG interpretation guidelines presented and the online training programme serve as an important foundation for improving the quality of ECG interpretations and the cardiovascular care of athletes.

Additional resources

For a free online training module on ECG interpretation in athletes, please visit: http://learning.bmj.com/ECGathlete. For the November 2012 BJSM supplement on “Advances in Sports Cardiology,” please visit: http://bjsm.bmj.com/content/46/Suppl_1.toc

References

View Abstract

Footnotes

  • Funding None.

  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.

  • ▸ References to this paper are available online at http://bjsm.bmjgroup.com

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