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CARDIAC TROPONINS AND NATRIURETIC PEPTIDES IN RUNNERS: USEFUL FOR CARDIAC RISK SCREENING?
  1. C Le Goff1,
  2. JF Kaux1,2,
  3. M Fillet2,
  4. P Mélon1,
  5. E Cavalier1,2
  1. 1University Hospital of Liège, Liège, Belgium
  2. 2University of Liège, Liège, Belgium

Abstract

Background Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency.

Objective Our aim was to compare cTnT and NT-proBNP levels before and after the stress tests, in sportive subjects.

Design Prospective, cohort study.

Setting Amateur marathon runners and ultrarunners.

Patients 28 subjects (26 men, 42.5±11 yrs) were enrolled.

Interventions Subjects ran the Maasmarathon (42.195 kilometers) and 33 subjects (33 men, 45.7±9.3 yrs) ran the Ultratour of Liège (Belgium; 67 km). All subjects gave their informed consent. We took blood sample before (T0), just after (T1) and 3 hours after the race (T3).

Main outcome measurements cTnT concentrations were measured by high sensitive methods (hsTnT, Roche Diagnostics) on heparin plasma. The NT-proBNP was also determined with the kit Roche on heparin plasma. All statistical analyses were performed using Medcalc version 8.1 for Windows. P-value <.01 was regarded as statistically significant.

Results A significant difference between hsTnT concentrations at T0 and T1 (P<.001), and between T0 and T3 (P<.001) for NT-proBNP have been observed, but not between T1 and T3. This observation appeared only after a strenuous exercise. However, up to now this type of exercise is not reproducible easily in a laboratory. Moreover, nobody knows if these observations would have cardiac consequences at long terms.

Conclusion Measurement of cardiac troponins by high sensitive methods allows detecting significant release of biomarkers from the heart during exercise. The value of NT-proBNP are also significant but less than TnThs. We think that the TnThs could be an interesting tool in the future to help sport medicine to detect risk of developing a cardiac problem in the future or a sudden death.

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