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What is the physiological time to recovery after concussion? A systematic review
  1. Joshua Kamins1,2,
  2. Erin Bigler3,
  3. Tracey Covassin4,
  4. Luke Henry5,
  5. Simon Kemp6,
  6. John J Leddy7,
  7. Andrew Mayer8,
  8. Michael McCrea9,
  9. Mayumi Prins10,
  10. Kathryn J Schneider11,
  11. Tamara C Valovich McLeod12,
  12. Roger Zemek13,
  13. Christopher C Giza1,2,14
  1. 1 Department of Neurosurgery, UCLA Steve Tisch BrainSPORT Program, Los Angeles, California, USA
  2. 2 UCLA Brain Injury Research Center, Los Angeles, California, USA
  3. 3 Department of Psychology and Neuroscience Center, Brigham Young University, Salt Lake City, Utah, USA
  4. 4 Michigan State University, East Lansing, Michigan, USA
  5. 5 Department of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  6. 6 Sports Medicine, Rugby Football Union, London, UK
  7. 7 Orthopaedics, SUNY Buffalo, Buffalo, New York, USA
  8. 8 The Mind Research Network, University of New Mexico, Albuquerque, New Mexico, USA
  9. 9 Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
  10. 10 Department of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, California, USA
  11. 11 Faculty of Kinesiology, University of Calgary, Calgary, Canada
  12. 12 Interdisciplinary Health Sciences, A.T. Still University, Mesa, Arizona, USA
  13. 13 Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada
  14. 14 Department of Pediatrics/Pediatric Neurology, Mattel Children's Hospital UCLA, Los Angeles, California, USA
  1. Correspondence to Dr Christopher C Giza, Department of Neurosurgery, UCLA Steve Tisch BrainSPORT Program, Room 531 Wasserman, 300 Stein Plaza, Los Angeles 90095, California, USA; cgiza{at}mednet.ucla.edu

Abstract

Aim or objective The aim of this study is to consolidate studies of physiological measures following sport-related concussion (SRC) to determine if a time course of postinjury altered neurobiology can be outlined. This biological time course was considered with respect to clinically relevant outcomes such as vulnerability to repeat injury and safe timing of return to physical contact risk.

Design Systematic review.

Data sources PubMed, CINAHL, Cochrane Central, PsychINFO.

Eligibility criteria for selecting studies Studies were included if they reported original research on physiological or neurobiological changes after SRC. Excluded were cases series <5 subjects, reviews, meta-analyses, editorials, animal research and research not pertaining to SRC.

Results A total of 5834 articles were identified, of which 80 were included for full-text data extraction and review. Relatively few longitudinal studies exist that follow both physiological dysfunction and clinical measures to recovery.

Summary/conclusions Modalities of measuring physiological change after SRC were categorised into the following: functional MRI, diffusion tensor imaging, magnetic resonance spectroscopy, cerebral blood flow, electrophysiology, heart rate, exercise, fluid biomarkers and transcranial magnetic stimulation. Due to differences in modalities, time course, study design and outcomes, it is not possible to define a single ‘physiological time window’ for SRC recovery. Multiple studies suggest physiological dysfunction may outlast current clinical measures of recovery, supporting a buffer zone of gradually increasing activity before full contact risk. Future studies need to use generalisable populations, longitudinal designs following to physiological and clinical recovery and careful correlation of neurobiological modalities with clinical measures.

  • Concussion
  • Sport psychology
  • Pathophysiology

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Footnotes

  • Acknowledgements We thank our UCLA Biomedical Librarian, Rikke Ogawa and her colleague Bethany Myers, who assisted with development of the search strategies and conducted the literature searches. We are also very grateful to Philip Rosenbaum for assisting with organisation of the project, managing the reference library and proofreading and Joshua Stanley for assisting in data extraction.

  • Competing interests JK—Fellowship partially supported by UCLA Steve Tisch BrainSPORT programme. EB—grants/research support: National Institute of Child Health and Human Development (grant Nos 5R01HD048946 and 3R01HD048946-05S1) and the USA. Army Medical Research and Material Command under Award No W81XWH-13-2-0095 (Chronic Effects of Neurotrauma Consortium); Director—Neuropsychological Research and Assessment Lab at BYU's Comprehensive Clinic. Medicolegal: Some forensic cases. TC—grants/research support: Brainscope, Datalys, Pentecost Foundation. SK—Chief Medical Officer, Rugby Football Union; Committee Member: World Rugby Head Injury Assessment Working Group and Football Association Independent Panel on Concussion and Head Injury. JJL—grants/research support: NIH, The Ralph C. Wilson Foundation, Program for Understanding Childhood Concussion and Stroke, The Robert Rich Family Foundation and The Buffalo Sabres Foundation. AM—grants/research support: NIH, US Dept of Defense, NSF. MMC—grants/research support: US Dept of Defense, US Dept of Veteran’s Affairs, NCAA, NFL-GE, GE Health Care, MCW CTSI, private donors; Consultant: Green Bay Packers; Past member: NFL Head, Neck and Spine Committee (w/o compensation); Member: GE Healthcare Medical Advisory Board, Board of Governors for International Neuropsychological Society. KJS—Consultant, Evidence Sport and Spinal Therapy; speaking honoraria for presentations at scientific meetings. TCVM—Trustee, United States Brain Injury Alliance; Senior Associate Editor: Journal of Athletic Training, Associate Editor: Journal of Sport Rehabilitation; Consultant, Concussion Health. RZ—grants/research support: CIHR, Ontario Neurotrauma Foundation, Ontario SPOR Support Unit, Clinical Research Chair in Pediatric Concussion, University of Ottawa Brain and Mind Institute. CCG—grants/research support: NIH, NCAA, US Department of Defense, Today’s and Tomorrow’s Children Fund, UCLA Brain Injury Research Center, UCLA Faculty Grants Program, UCLA Steve Tisch BrainSPORT programme, Avanir (research grant 2017-2018), NINDS Neural Analytics SBIR grant (2016-2018); Consultant: NFL—Neurological Care Program, NHLPA, Neural Analytics Inc (2015-16); Advisory Panel: LoveYourBrain, MLS, NBA, NCAA, USSF; Medicolegal: One or two cases annually; Speaker’s Bureau: Medical Education Speakers Network.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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