Cell adhesion molecules are proteins expressed on the surface of a variety of cells and mediating the leukocyte response to inflammation. Some of these molecules are released to the plasma as soluble forms, whose presence indicates the degree of vascular endothelial activation or dysfunction. Elevated concentrations of soluble adhesion molecules are thought to hamper the immune response and mediate the atherosclerotic inflammatory process. Studies on the effect of exercise on the concentrations of soluble adhesion molecules have employed almost exclusively aerobic exercise. In this study we assessed the effect of resistance exercise on the serum concentrations of 5 cell adhesion molecules during and immediately after 30 min of exercise in lean and obese subjects. Fourteen healthy young men (8 lean and 6 obese) performed 3 sets of 10 resistance exercises with 10-12 repetitions at 70- 75% of 1RM in a circuit training fashion. Venous blood samples were drawn at baseline and at the end of the first, second, and third sets. The serum concentrations of vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, E-selectin, P-selectin, and L- selectin were measured in a biochip array analyser. There were no significant changes in the concentrations of these cell adhesion molecules during exercise and no differences between lean and obese subjects. Our data indicate that resistance exercise of moderate to high intensity does not affect the serum concentrations of cell adhesion molecules in healthy young lean and obese males, suggesting no considerable negative effect on immune function.
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