Objective: To study the effects of an acute therapeutic oral intake of beta-2 agonist on performance and substrate response during supramaximal exercise in women.
Methods: Twelve healthy moderately trained female volunteers performed a Wingate test after ingestion of placebo (Pla) and salbutamol (Sal, 4 mg) according to a double-blind randomized cross-over study. Blood samples were collected at rest, at the end of exercise and after 5 (r5) , 10 (r10), and 15 (r15) min of passive recovery for ACTH, growth hormone, insulin, blood glucose and lactate measurements.
Results: Peak and mean power significantly increased whereas time to peak power was significantly shorter with Sal compared to Pla (p<0.05). No change was observed in the fatigue index. ACTH was not significantly modified but r15 GH significantly decreased (p<0.05) after Sal intake. Both blood INS and blood glucose were significantly increased by Sal during all the experiment (p<0.01). Blood lactate was significantly increased by Sal vs Pla (p<0.05) after 10 and 15 min of passive recovery.
Conclusion: From these data, acute therapeutic oral intake of salbutamol appears to induce, irrespective of the subjects' gender, an improvement in performance during a supramaximal exercise, i.e., increase in peak power and mean power. Further studies are necessary to clarify whether the mechanisms involved in the response to salbutamol are linked to central and/or peripheral pathways.
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