Objective: To study the effects of an acute therapeutic oral intake of beta-2 agonist on performance and substrate response during supramaximal exercise in women.
Methods: Twelve healthy moderately trained female volunteers performed a Wingate test after ingestion of placebo (Pla) and salbutamol (Sal, 4 mg) according to a double-blind randomized cross-over study. Blood samples were collected at rest, at the end of exercise and after 5 (r5) , 10 (r10), and 15 (r15) min of passive recovery for ACTH, growth hormone, insulin, blood glucose and lactate measurements.
Results: Peak and mean power significantly increased whereas time to peak power was significantly shorter with Sal compared to Pla (p<0.05). No change was observed in the fatigue index. ACTH was not significantly modified but r15 GH significantly decreased (p<0.05) after Sal intake. Both blood INS and blood glucose were significantly increased by Sal during all the experiment (p<0.01). Blood lactate was significantly increased by Sal vs Pla (p<0.05) after 10 and 15 min of passive recovery.
Conclusion: From these data, acute therapeutic oral intake of salbutamol appears to induce, irrespective of the subjects' gender, an improvement in performance during a supramaximal exercise, i.e., increase in peak power and mean power. Further studies are necessary to clarify whether the mechanisms involved in the response to salbutamol are linked to central and/or peripheral pathways.
- Beta-2 agonist
- oral administration
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.