Objective: Given the therapeutic and non therapeutic use of the tadalafil, (phosphodiesterase-5 inhibitor, PDE-5i), we examined its effects on anaerobic performance indices.
Methods: Twelve well-trained subjects reported to the laboratory on two occasions one week apart to perform a 30-s Wingate anaerobic power test (WAnT) on a bicycle ergometer. The day prior the WAnT the subjects received in a double-blind manner an oral dose of tadalafil (20 mg) or placebo. Blood lactate value at rest and 1’, 3’, 6’, 10’ min of recovery phase, mean power, peak power, time to peak power and fatigue index were assessed for each WAnT.
Results: Blood lactate values at the 3’ min recovery WAnT increased significantly in the tadalafil condition (mean (SD) 13.9 (1.7) v 12.8 (1.3) mmol/l; p<0.05), and time to peak power decreased significantly (6.3 (1.3) v 5.7 (1.5) s; p=0.05). No differences were observed in any other parameters between the two conditions.
Conclusion: The primary finding of this investigation was that the administration of a single dose of a long-term PDE-5i does not substantially influence anaerobic performance indices. However, results demonstrated both an increase in lactate values at 3 min of the recovery phase and a decrease in time to peak power.
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