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Creatine supplementation does not affect clinical health markers in soccer players
  1. Paula Cancela (nelipau2005{at}
  1. Facultad de Ciencias, Universidad de la República, Uruguay
    1. Carlos Ohanian (cohanianh{at}
    1. Hospital de Clínicas, Universidad de la República, Uruguay
      1. Eduardo Cuitiño (cuitinio{at}
      1. Centro de Matemáticas, Facultad de Ciencias, Universidad de la República, Uruguay
        1. Anthony C. Hackney
        1. Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, United States


          Purpose: To study the effects of 8 wk creatine monohydrate (CrM) supplementation on blood and urinary clinical health markers in soccer players.

          Methods: 14 soccer players were randomly assigned in a double-blinded fashion to Cre (N = 7) or Pla (N = 7) group. Cre group ingested 15 g/d of CrM during 7 d, and 3 g/d for the remaining 49 d, whereas the Pla group ingested maltodextrin following the same protocol. Soccer-specific training was performed during the study. Total body mass was determined and blood and urine samples were analized for metabolic, hepatic, renal and muscular function markers, before and after supplementation.

          Results: A gain of total body mass was observed after CrM intake, not with placebo. Blood and urinary markers remained within normal reference values. There were no significant changes in renal and hepatic markers after CrM intake. However, total CK activity significantly increased, and uric acid level tended to decrease after CrM use. Likewise, serum glucose decreased in the Cre group following supplementation. No significant differences in urine parameters were found in either group after supplementation.

          Conclusions: 8 wk of CrM supplementation had no negative effect on blood and urinary clinical health markers in soccer players. Properties of CrM may, however, be associated with an increase in CK activity, improving the efficiency for ATP resynthesis, phenomenon indirectly confirmed by the decreasing tendency in uric acid concentration. Furthermore, CrM seems to slightly influence glucoregulation in trained subjects.

          • Creatine monohydrate
          • Glucose
          • creatine kinase
          • soccer
          • uric acid

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          • Miscellaneous
            BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine
          • Original article
            P Cancela C Ohanian E Cuitiño A C Hackney