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Short-term glucocorticoid intake combined with intense training on performance and hormonal responses
  1. Katia Collomp (katia.collomp{at}
  1. LAPSEP, UFR STAPS Orléans; Département des Analyses, AFLD, France
    1. Alexandre Arlettaz (alexandre.arlettaz{at}
    1. LAPSEP, UFR STAPS Orléans, France
      1. Hugues Portier (hugues.portier{at}
      1. LAPSEP, UFR STAPS Orléans, France
        1. Anne-Marie Lecoq (anne-marie.lecoq{at}
        1. Sports Medicine Service, CHR Orléans; LAPSEP, UFR STAPS Orléans, France
          1. Bénédicte Le Panse (lepansebenedicte{at}
          1. LAPSEP, UFR STAPS Orléans, France
            1. Nathalie Rieth (nathalie.rieth{at}
            1. LAPSEP, UFR STAPS Orléans, France
              1. Jacques De Ceaurriz (analyses{at}
              1. Département des Analyses, AFLD, France


                Objective: To investigate the effects of short-term prednisolone ingestion combined with intense training on exercise performance, hormonal (ACTH, PRL, LH, GH, TSH, DHEA, testosterone, insulin) and metabolic parameters (blood glucose, lactate, bicarbonate, pH). Methods: Eight recreational male athletes completed four cycling trials at 70-75% peak O2 consumption until exhaustion just before (1) and after (2) either oral placebo (Pla) or prednisolone (Cor, 60mg/day for 1 wk) treatment coupled to a standardized physical training (2 hours/day), according to a double-blind and randomized protocol. Blood samples were collected at rest, during exercise and passive recovery for the hormonal and metabolic determinations. Results: Time of cycling was not significantly changed after Pla but significantly increased (P<0.05) after Cor administration (Pla1: 50.4 ± 6.2; Pla2: 64.0 ± 9.1; Cor1: 56.1 ± 9.1; Cor2: 107.0 ± 20.7 min). There was no significant difference in any measured parameters after the week of training with Pla but a decrease in ACTH, DHEA, testosterone, PRL, GH and TSH was observed with Cor treatment during the experiment (P<0.05). No significant change in basal, exercise or recovery LH, insulin, lactate, pH or bicarbonate was found between the 2 treatments but blood glucose was significantly higher under Cor (P<0.05) at any moment. Conclusion: It is concluded that short-term glucocorticoid administration induced a marked improvement in endurance performance and further studies are needed to determine whether these results obtained in recreational male athletes maintaining a rigorous training schedule are gender dependent and applicable to elite athletes.

                • exercise endurance
                • physical training
                • pituitary hormones
                • prednisolone
                • testosterone

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