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Br J Sports Med doi:10.1136/bjsm.2007.043943

Effects of exercise intensity on lymphocyte H2O2 production and antioxidant defences in soccer players

  1. Antoni Sureda (tosugo{at}hotmail.com)
  1. Departament de Biologia Fonamental i Ciències de la Salut. Universitat de les Illes Balears, Spain
    1. Miguel D Ferrer (mothglin{at}gmail.com)
    1. Departament de Biologia Fonamental i Ciències de la Salut. Universitat de les Illes Balears, Spain
      1. Pedro Tauler (ptr20{at}bath.ac.uk)
      1. Departament de Biologia Fonamental i Ciències de la Salut. Universitat de les Illes Balears, Spain
        1. Dora Romaguera (doraromaguera{at}yahoo.es)
        1. Departament de Biologia Fonamental i Ciències de la Salut. Universitat de les Illes Balears, Spain
          1. Franchek Drobnic
          1. Medical Services. F.C. Barcelona, Spain
            1. Pere Pujol
            1. Sports Physiology Department. Centre d’Alt Rendiment de Barcelona, Barcelona, Spain, Spain
              1. Josep A Tur (pep.tur{at}uib.es)
              1. Departament de Biologia Fonamental i Ciències de la Salut. Universitat de les Illes Balears, Spain
                1. Antoni Pons (antonipons{at}uib.es)
                1. Departament de Biologia Fonamental i Ciències de la Salut. Universitat de les Illes Balears, Spain
                  • Published Online First 10 December 2007

                  Abstract

                  Objective: Physical exercise is capable to enhance or suppress the immune response depending on the intensity and duration of exercise. We studied how exercise intensity influences the lymphocyte antioxidant response and the induction of cellular oxidative damage. Design: Eighteen voluntary male pre-professional soccer players participated in this study. Sportsmen played a 60 minutes training match, and were divided in three groups depending on the intensity degree during the match: low, medium and high intensities. Measurements: Malondialdehyde (MDA), vitamins C and E and heme oxigenase-1 (HO-1) gene expression were measured in lymphocytes. Reactive oxygen species (ROS) production were determined in lymphocytes and neutrophils. Results: Lymphocyte MDA levels and H2O2 production were significantly increased in the group which performed the most intense exercise. Neutrophil counts and ROS production increased progressively with the exercise intensity. Vitamin C significantly decreased after exercise in the highest intensity group respect to initial values, whereas vitamin E levels significantly increased in the medium and high intensity groups. HO-1 gene expression significantly increased in the medium and high intensity groups. Conclusions: Exercise intensity affects the lymphocyte and neutrophil oxidant/antioxidant balance, but only exercise of high intensity induces lymphocyte oxidative damage.

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