Objective: To answer the question if the exercise-induced immune response contributes to the exercise-induced increase in Brain Natriuretic Peptide (BNP) in healthy athletes. This has previously been speculated as elevated concentrations of BNP or NT-proBNP in cardiovascular patients were found to be related to immune reactions and elevations in inflammatory cytokines such as interleukin 6 (IL-6).
Methods: We analysed stored serum samples on NT-proBNP concentrations of 14 healthy endurance athletes (age: 25 5years; VO2max: 67 6 ml•min-1•kg-1), who had been examined previously on exercise-induced immune reactions and its dependence on carbohydrate supplementation (6 or 12% CHOS; placebo) after three bouts of 4h cycling at a given workload of 70% of the individual anaerobic threshold. Venous blood samples were taken before, immediately, 1h and 1 day after exercise. Leukocyte-subpopulations were determined immediately after blood sampling by flow cytometry. Serum samples for posterior analysis of CRP, IL-6, cortisol and NT-proBNP (Elecsys®proBNP, Roche Diagnosics) were stored at -80°C.
Results: The exercise-induced increases in NT-proBNP (p<0.001) were not related to the exercise-induced immune response, although exercise induced significant (CHOS-dependent) increases in IL-6, CRP, cortisol, leukocytes, neutrophils, monocytes and natural-killer-cells.
Conclusion: It is unlikely that the exercise-induced increases in NT-proBNP or BNP in healthy athletes are caused by the exercise-induced immune response. Therefore, exercise-induced increases in NT-proBNP or BNP in healthy athletes have to be differentiated from increases in cardiovascular patients with systemic inflammation.
- athletes heart
- heart failure
- natriuretic peptides
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.