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Br J Sports Med doi:10.1136/bjsm.2007.042945

NRF-1 genotypes and endurance exercise capacity in young Chinese men

  1. zihong HE (zihong_he{at}hotmail.com)
  1. China Institute of Sport Science, China
    1. yang HU (bsugene{at}yahoo.com)
    1. Beijing Sport University, China
      1. lianshi FENG (fengls{at}yahoo.com.cn)
      1. China Institute of Sport Science, China
        1. yanchun LI (lych1216{at}hotmail.com)
        1. Beijing Sport University, China
          1. gang LIU (liugang{at}sina.com)
          1. Beijing Sport University, China
            1. yi XI (xiyi{at}sina.com)
            1. Tianjin Institute of Physical Education, China
              1. li WEN (wenli{at}sina.com)
              1. Tianjin Institute of Physical Education, China
                1. Alejandro Lucia (alejandro.lucia{at}uem.es)
                1. Universidad Europea de Madrid, Madrid, Spain
                  • Published Online First 9 January 2008

                  Abstract

                  Background: Nuclear respiratory factor 1 (NRF-1) is a critical component of the energy-sensing mechanism in mammalian cells, i.e., by translating physiological signals (particularly, those induced by exercise) into increased capacity for mitochondrial biogenesis and oxidative phosphorylation.

                  Objective: Our purpose was to study the possible association between rs2402970, rs6949152 and rs10500120 NRF-1 genotypes and several phenotypes indicatives of maximal (VO2max) and submaximal aerobic capacity [ventilatory threshold (VT) and metabolic cost of submaximal running at 12 km•h-1 (running economy, RE)] both at baseline and in response to a 18-week endurance training program in Chinese young males of Han origin (N = 102; 19? years).

                  Results: For rs2402970, a significant genotype effect was observed in VT (P=0.004) and RE (P=0.027). For rs6949152, a significant interaction (genotype x training) effect (P=0.047) existed in VT.

                  Conclusions: There exists an association between NRF-1 genotypes (rs2402970 and rs6949152 polymorphisms) and the baseline and/or training response of human aerobic capacity. More research is needed to corroborate our data in other ethnic groups with lower fitness levels at the pre-training state (particularly Caucasians) and to identify the molecular mechanisms involved in the genotype-phenotype associations we found.

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