Article Text

other Versions

PDF
Circulating substance P levels and shoulder joint contracture after arthroscopic repair of the rotator cuff
  1. Francesco Franceschi
  1. Department of Orthopaedics, Campus Biomedico University, Via Longoni, 83, 00155 Rome, Italy
    1. Umile Giuseppe Longo
    1. Department of Orthopaedics, Campus Biomedico University, Via Longoni, 83, 00155 Rome, Italy
      1. Laura Ruzzini
      1. Department of Orthopaedics, Campus Biomedico University, Via Longoni, 83, 00155 Rome, Italy
        1. Fabrizio Battistoni
        1. Department of Laboratory Medicine and Microbiology, Campus Biomedico University, Rome, Italy
          1. Sergio Morini
          1. Department of Surgical Pathology, Campus Biomedico University, Via Longoni, 83, 00155 Rome, Italy, Italy
            1. Giordano Dicuonzo
            1. Department of Laboratory Medicine and Microbiology, Campus Biomedico University, Rome, Italy
              1. Nicola Maffulli (osa14{at}keele.ac.uk)
              1. Keele University School of Medicine, United Kingdom
                1. VINCENZO Denaro
                1. Department of Orthopaedics, Campus Biomedico University, Via Longoni, 83, 00155 Rome, Italy

                  Abstract

                  Objective: To determine the plasma levels of substance P (SP) in patients with postoperative stiffness after arthroscopic rotator cuff repair.

                  Design: Plasma samples were obtained at 15 months from surgery from 2 groups of patients who underwent arthroscopic repair of a rotator cuff tear. In Group 1, 30 subjects (14 men and 16 women, mean age: 64.6 years, range 47 to 78) with shoulder stiffness 15 months after arthroscopic rotator cuff repair were recruited. In Group 2, 30 patients (11 men and 19 women, mean age: 57.8 years, range 45 to 77) were evaluated 15 months after successful arthroscopic rotator cuff repair. Immunoassays were performed with commercially available assay kits to detect the plasma levels of SP.

                  Results: The mean plasma levels of SP in patients with postoperative stiffness were significantly greater than those in the control group (81.06 ± 27.76 versus 23.49 ± 5.64, P < 0.05).

                  Conclusions: The plasma concentrations of substance P in patients with shoulder stiffness after arthroscopic rotator cuff repair are higher compared to plasma levels of SP in patients with a good postoperative outcome. The neuronal up-regulation of SP shown in the plasma of patients with post operative shoulder stiffness may underlay not only the symptoms of adhesive capsulitis, but also its development.

                  Statistics from Altmetric.com

                  Request permissions

                  If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.