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Mobilisation of mesenchymal cells in cardiac patients: is intense exercise necessary?
  1. Alejandro Lucia (alejandro.lucia{at}uem.es)
  1. Universidad Europea de Madrid, Spain
    1. Alejandro De La Rosa (adelarosahdez{at}gmail.com)
    1. Hospital Universitario de La Laguna, Gran Canarias, Spain
      1. Marta Avila Silván (marta.avila{at}uem.es)
      1. Universidad Europea de Madrid, Spain
        1. Luis M López-Mojares (lmiguel.lopez{at}uem.es)
        1. Universidad Europea de Madrid, Spain
          1. Araceli Boraita (araceli.boraita{at}csd.mec.es)
          1. Servicio de Cardiología, Consejo Superior de Deportes, Spain
            1. Margarita Pérez (margarita.perez{at}uem.es)
            1. Universidad Europea de Madrid, Spain
              1. Carl Foster (foster.carl{at}uwlax.edu)
              1. 1University of Wisconsin-La Crosse, United States
                1. Javier García-Castro (javier.garcia.castro.exts{at}juntadeandalucia.es)
                1. Banco Andaluz de Células Madre (BACM), Centro de Investigaciones BiomédicasGranada, Spain
                  1. Manuel Ramirez (mramirezo.hnjs{at}salud.madrid.org)
                  1. Hospital Infantil Universitario Niño Jesús, Spain

                    Abstract

                    Circulating mesenchymal cells (cMCs) have the potential for regenerating damaged tissue, e.g., ischemic myocardium. In patients (age range: 53-76 yrs) with stable coronary artery disease we determined cMCs before and after dynamic exercise of moderate (< respiratory compensation threshold (RCT)) (n=9 patients) or high intensity (> RCT) (n=11). Only high-intensity exercise (i.e., provoking signs of myocardial ischemia in 3 patients and ventricular extrasystoles in another) induced a significant increase in cMCs (P = 0.009). Our results support the hypothesis that intense exercise (near or at the point of myocardial ischemia) is a potent stimulus for MCs mobilisation.

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