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Characterizing Cortical Density in the Mid-Tibia: Intra-Individual Variation in Adolescent Girls
  1. David M.L. Cooper (dml.cooper{at}
  1. University of Saskatchewan, Canada
    1. Yasmin Ahamed (yasmina{at}
    1. University of British Columbia, Canada
      1. Heather M. Macdonald (hmacdona{at}
      1. University of Calgary, Canada
        1. Heather McKay (mckayh{at}
        1. University of British Columbia, Canada


          Introduction: Inter-individual differences in cortical bone volumetric density (CoD), such as those related to sex, are a product of differences in remodeling rates. While cortical bone is often treated as a uniform tissue, remodeling rates also vary within individual bones. This level of adaptation has largely been overlooked in analyses of peripheral quantitative computed tomography (pQCT) images. Further, such variation in CoD has never been assessed in growing bones. We hypothesized that CoD varied significantly within the same cross-section of the mid-tibia of adolescents. We further hypothesized that due to the profound impact of estrogen on remodeling, this variation would be different between sexes.

          Methods: Subjects were 183 adolescents (99 girls and 84 boys) in grade 6 and 7 with a mean age of 12.1 years. We used age at peak height velocity to adjust for maturational differences between sexes. Image data from a mid-tibia pQCT scan of each subject was assessed regionally within 8 sectors distributed about the cortex and aligned by the anterior tibial crest. We used a repeated measures general linear model to assess intra-individual variation in CoD while controlling for differences in ethnicity, maturity, height, weight, physical activity level and total cross-sectional bone area (ToA).

          Results: Sector-based variation in CoD was significant (p<0.001) with the anterior cortex having lower density than the posterior cortex. The largest percent difference (anterior vs. postero-medial sectors) was 12.2%. A significant sector*sex interaction (p=0.018) was detected; however, its impact was relatively small with girls having 1.1% to 3.6% denser bones than boys depending on the sector (2.7% average difference).

          Conclusions: The magnitude of the variation in CoD across sectors within individuals of both sex was far greater than the mean differences between the sexes. This finding indicates that the microstructural variation within the mid-tibia is detectable by pQCT and its magnitude suggests an important level of adaptation to loading.

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